Measles virus nucleocapsid protein increases osteoblast differentiation in Paget’s disease
نویسندگان
چکیده
منابع مشابه
Measles virus nucleocapsid protein modulates the Signal Regulatory Protein-β1 (SIRPβ1) to enhance osteoclast differentiation in Paget's disease of bone☆
Paget's disease of bone (PDB) is a chronic localized bone disorder in an elderly population. Environmental factors such as paramyxovirus are implicated in PDB and measles virus nucleocapsid protein (MVNP) has been shown to induce pagetic osteoclasts (OCLs). However, the molecular mechanisms underlying MVNP stimulation of OCL differentiation in the PDB are unclear. We therefore determined the MV...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2016
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci82012